Description
Letrozole is an anti-estrogen in the aromatase inhibitor (AI) family and is one of the most powerful and potent of all AIs. In fact, its power is sometimes too great for some when it is used for off-label use. Letrozole was approved for the first time by the FDA in the United States in 1997 and would be marketed under the brand name Femara through Novartis. Although Femara is the dominant commercial name for AI, unlike most AIs, it is the only one, generally known by its chemical name, Letrozole, much more often than its dominant brand name.
Letrozole was first developed as part of an effort to combat breast cancer in postmenopausal women. In fact, it would be virtually identical to the AI already popular in Arimidex (Anastrozole). Although designed for breast cancer treatment, like many AIs, it has found favor among users of anabolic steroids. Letrozole is one of the most commonly used anti-estrogens in steroid users when steroids are used to combat possible estrogen-related side effects. It is so effective as an antiestrogen in this regard that many anabolic steroids have effectively reversed the symptoms of gynecomastia with letrozole.
Letrozole also has the ability to increase natural testosterone production through an increase in luteinizing hormone (LH) and follicle stimulating hormone (FSH). Some doctors have chosen it because it is often known to treat low testosterone conditions, but this is not usually the preferred treatment method. Without a doubt, exogenous testosterone is usually the only thing that makes sense when it comes to low testosterone treatment. However, letrozole may be useful in such a plan in conjunction with exogenous testosterone to combat possible side effects. We will look at this in the effects section.
Dosage
The recommended recommended dose of letrozole is 2.5 mg once daily. No dose adjustment is necessary in the elderly patient.
Side Effects :
The side effects of letrozole will cover a wide range and will be very similar to those of Arimidex. Weakness and fatigue are two of the most common side effects of letrozole use. However, for the anabolic steroid user, this will not normally be a problem. The use of anabolic steroids should prevent such conditions, as long as the suppression of estrogen is not too extensive. The exception would be its use during a cycle of preparation for the hard bodybuilding contest. During a hard bodybuilding diet, the individual will normally be very weak and fatigue at the end of his diet due to extremely intense workouts and a very low caloric intake. In addition to possible energy problems, the most common side effects are:
Headache
Hypertension
Hot flashes
Articular pain
Depression
Letrozole has also been shown to significantly reduce bone mineral content, which may increase the risk of osteoporosis.
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